Vom Anschauen zum Hinschauen. Zum Lernen mit digitalen Medien am Beispiel der Computerkunst

Digitale Medien besitzen Eigenschaften, die es Lernenden erlauben, neue Zugangsweisen zur Welt zu entdecken. Das ist eine gewagte Behauptung. Wir werden versuchen, sie näher zu begründen und ihr Gestalt zu verleihen. Wir tun dies anhand von Beispielen aus dem Bereich der Computerkunst – anhand technischer Bilder. Wir setzen dazu bei Vilém Flusser (1999) an, der uns darauf hinweist, dass technische Bilder anders zu verstehen seien als traditionelle. Dieses Verständnis der technischen Bilder möchten wir auf den besonderen Charakter vieler Computerdinge hin verallgemeinern. Dies führt uns zu Vorschlägen zur Gestaltung von digitalen Medien für Lernumgebungen, insbesondere ihrer Eigenschaft der Interaktivität. Wir enden mit einem Beispiel der praktischen Umsetzung einer konstruktivistisch fundierten Lernumgebung aus unserem Forschungsprojekt COMPART: Ein RAUM FÜR DIE COMPUTERKUNST. Abschließend fragen wir nach der Eignung der Terme Flussers in Bezug auf dieses Projekt

A low-profile user terminal antenna for mobile bi-directional Ka-band satellite communications

This paper presents a low-profile user-terminal antenna for mobile bi-directional Ka-band satellite communication networks for emergency scenarios. We have devised an antenna with a circularly polarised radiation pattern and dual-band capability, which addresses a hybrid tracking. The principle of operation of a rectangular antenna panel applying a dual-band partially reflective surface (PRS) of 60 mm by 200 mm was manufactured and successfully verified. This publication describes the design of the panel and analyses measurement results. Furthermore, our first low-profile antenna demonstrator is presented, intended to be evaluated at a testbed for satellite communications in Ilmenau.Publikation entstand im Rahmen der Veranstaltung: 34th ESA Antenna Workshop on Satcom User Terminal Antennas, ESA/ESTEC, Noordwijk, The Netherlands, 3-5 October 2012, 5 S. insg

Low-profile antenna for mobile Ka-band satellite communications

This paper describes the concept of a low-profile user terminal antenna intended for mobile bi-directional Ka-band satellite communications. The concept addresses a hybrid electronic and mechanical tracking method. The antenna consists of several two-dimensional leaky-wave antenna panels. Each panel is excited by a slotted waveguide feed, composed of a linear array of circularly polarised slots. This structure offers a reconfigurable radiation pattern. As a proof-of-principle, a rectangular antenna panel for the downlink at 20 GHz was manufactured and measured. The paper describes the design of the panel in detail and presents the results of numerical simulation and measurement

Natural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors

BACKGROUND: Atypical teratoid/rhabdoid tumors (AT/RT) are highly aggressive CNS tumors of infancy and early childhood. Hallmark is the surprisingly simple genome with inactivating mutations or deletions in the SMARCB1 gene as the oncogenic driver. Nevertheless, AT/RTs are infiltrated by immune cells and even clonally expanded T cells. However, it is unclear which epitopes T cells might recognize on AT/RT cells. METHODS: Here, we report a comprehensive mass spectrometry (MS)-based analysis of naturally presented human leukocyte antigen (HLA) class I and class II ligands on 23 AT/RTs. MS data were validated by matching with a human proteome dataset and exclusion of peptides that are part of the human benignome. Cryptic peptide ligands were identified using Peptide-PRISM. RESULTS: Comparative HLA ligandome analysis of the HLA ligandome revealed 55 class I and 139 class II tumor-exclusive peptides. No peptide originated from the SMARCB1 region. In addition, 61 HLA class I tumor-exclusive peptide sequences derived from non-canonically translated proteins. Combination of peptides from natural and cryptic class I and class II origin gave optimal representation of tumor cell compartments. Substantial overlap existed with the cryptic immunopeptidome of glioblastomas, but no concordance was found with extracranial tumors. More than 80% of AT/RT exclusive peptides were able to successfully prime CD8(+) T cells, whereas naturally occurring memory responses in AT/RT patients could only be detected for class II epitopes. Interestingly, >50% of AT/RT exclusive class II ligands were also recognized by T cells from glioblastoma patients but not from healthy donors. CONCLUSIONS: These findings highlight that AT/RTs, potentially paradigmatic for other pediatric tumors with a low mutational load, present a variety of highly immunogenic HLA class I and class II peptides from canonical as well as non-canonical protein sources. Inclusion of such cryptic peptides into therapeutic vaccines would enable an optimized mapping of the tumor cell surface, thereby reducing the likelihood of immune evasion

Multiband Observations of the Quasar PKS 2326-502 during Active and Quiescent Gamma-Ray States in 2010-2012

Quasi-simultaneous observations of the Flat Spectrum Radio Quasar PKS 2326-502 were carried out in the γ-ray, X-ray, UV, optical, near-infrared, and radio bands. Using these observations, we are able to characterize the spectral energy distribution (SED) of the source during two flaring and one quiescent γ-ray states. These data were used to constrain one-zone leptonic models of the SEDs of each flare and investigate the physical conditions giving rise to them. While modeling one flare required only changes in the electron spectrum compared to the quiescent state, modeling the other flare required changes in both the electron spectrum and the size of the emitting region. These results are consistent with an emerging pattern of two broad classes of flaring states seen in blazars. Type 1 flares are explained by changes solely in the electron distribution, whereas type 2 flares require a change in an additional parameter. This suggests that different flares, even in the same source, may result from different physical conditions or different regions in the jet